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rpb1 DNA-directed RNA polymerase II complex large subunit Rpb1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540292, updated on 18-Sep-2024

Summary

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Official Symbol
rpb1
Official Full Name
DNA-directed RNA polymerase II complex large subunit Rpb1
Primary source
PomBase:SPBC28F2.12
Locus tag
SPOM_SPBC28F2.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rpb1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003423.3 (1591140..1596744)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene upstream binding transcription factor, RNA polymerase I specific, Hmo1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Asn

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional profiling of fission yeast RNA polymerase II CTD mutants. Garg A, et al. RNA, 2021 Feb 12. PMID 33579781, Free PMC Article
  2. Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Schwer B, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24591591, Free PMC Article
  3. Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Morris SA, et al. Eukaryot Cell, 2005 Aug. PMID 16087749, Free PMC Article
  4. Centromere DNA Destabilizes H3 Nucleosomes to Promote CENP-A Deposition during the Cell Cycle. Shukla M, et al. Curr Biol, 2018 Dec 17. PMID 30503616, Free PMC Article
  5. Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein. Larochelle M, et al. Curr Genet, 2017 May. PMID 27582274

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.
    Title: A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.
  2. Seb1 is critical for poly(A) site selection by binding to the C-terminal domain (CTD) of RNAPII via a conserved CTD-interaction domain and recognizes specific sequence motifs clustered downstream of the polyadenylation site on the uncleaved pre-mRNA.
    Title: Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein.
  3. Examination of the roles of known Rpb1 phosphorylation sites in co-transcriptional histone modifications.
    Title: Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.
  4. Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast.
    Title: Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast.
  5. Separate domains of Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
    Title: Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II activity EXP
Inferred from Experiment
more info
 PubMed 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin-protein adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables chromatin-protein adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin-protein adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chromatin-protein adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin-protein adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 PubMed 
involved_in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular phosphate ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase II transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II EXP
Inferred from Experiment
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II, holoenzyme EXP
Inferred from Experiment
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 

General protein information

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Preferred Names
DNA-directed RNA polymerase II complex large subunit Rpb1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    1591140..1596744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021568.3 → NP_595673.1  DNA-directed RNA polymerase II complex large subunit Rpb1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595673.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36594
    Conserved Domains (3) summary
    cd02584
    Location:1038 → 1452
    RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
    cd02733
    Location:18 → 859
    RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
    pfam04992
    Location:879 → 1059
    RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6
Nucleotide Protein
Heading Accession and Version

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